Vildagliptin

Generic Details

Generic Name

Vildagliptin

Other Names

  • Galvus

Drug Class

  • Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Chemical Formula

C17H25N3O2

Molecular Weight

303.4 g/mol

Mechanism of Action

  • Increases insulin secretion
  • Decreases glucagon production

Indications

  • Type 2 Diabetes Mellitus

Common Dosage Forms

  • Tablet

Typical Dosage

  • 50 mg twice daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Dose adjustment may be required

Side Effects

  • Hypoglycemia
  • Headache
  • Upper respiratory tract infection
  • Nasopharyngitis

Contraindications

  • Hypersensitivity to vildagliptin
  • Type 1 Diabetes Mellitus

Pregnancy Category

  • Category B

Lactation Safety

  • Use with caution

Drug Interactions

  • CYP3A4 inducers/inhibitors
  • ACE Inhibitors

Overdose Symptoms

  • Hypoglycemia

Antidote for Overdose

  • Glucose or glucagon

Storage Conditions

  • Store at room temperature (15-30°C)

Pharmacokinetics

  • Absorption: Rapidly absorbed
  • Distribution: Highly protein bound
  • Metabolism: Hepatic via cytochrome P450 enzymes
  • Excretion: Mainly in urine

Precautions

  • Renal impairment
  • Hepatic impairment

Warnings

  • Monitor renal function regularly

Others

  • Vildagliptin is generally well tolerated and can be used alone or in combination with other antidiabetic medications.