Vinpocetine
Generic Details
Generic Name
Vinpocetine
Other Names
- Cavinton
Drug Class
- Cerebral vasodilator
Chemical Formula
C22H26N2O2
Molecular Weight
350.454 g/mol
Mechanism of Action
- Vinpocetine is a synthetic derivative of vincamine, a natural substance found in the periwinkle plant. It enhances cerebral blood flow, improves brain metabolism, and acts as a neuroprotective agent.
Indications
- Treatment of cognitive impairment and dementia
- Improving memory and cognitive function
- Enhancing cerebral circulation
Common Dosage Forms
- Tablets
- Capsules
Typical Dosage
- 5-10 mg three times a day with meals
Pediatric Dosage
- Not recommended for use in children
Geriatric Dosage
- Lower initial doses may be required in the elderly
Side Effects
- Headache
- Nausea
- Dizziness
- Nervousness
- Flushing
Contraindications
- Hypersensitivity to vinpocetine
- Bleeding disorders
- Recent major surgery
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Safety during lactation is not established; consult a healthcare provider
Drug Interactions
- Anticoagulants
- Antiplatelet drugs
- Blood thinners
Overdose Symptoms
- Hypotension
- Severe headache
- Gastrointestinal disturbances
Antidote for Overdose
- There is no specific antidote; treatment is symptomatic and supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Crosses the blood-brain barrier; widely distributed in body tissues
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in the urine
Precautions
- Caution in patients with hypotension
- Monitor for signs of bleeding
Warnings
- Discontinue use if signs of allergic reaction occur
- Avoid use before surgery due to potential bleeding risk
Others
- Vinpocetine may interact with other medications; consult a healthcare provider before use.