Xylometazoline Hydrochloride
Generic Details
Generic Name
Xylometazoline Hydrochloride
Other Names
- Xylometazoline HCl
- Xylometazoline HCI
Drug Class
- Nasal decongestant
Chemical Formula
C16H24N2Cl
Molecular Weight
284.82 g/mol
Mechanism of Action
- Sympathomimetic
Indications
- Nasal congestion
- Rhinitis
- Sinusitis
Common Dosage Forms
- Nasal spray
- Nasal drops
Typical Dosage
- 0.1% solution: 2-3 drops in each nostril every 10-12 hours
Pediatric Dosage
- Consult pediatrician for appropriate dosing
Geriatric Dosage
- Lower initial dose may be needed in the elderly
Side Effects
- Nasal dryness
- Rebound congestion
- Burning sensation in the nasal mucosa
Contraindications
- Hypersensitivity to xylometazoline
- Severe hypertension
Pregnancy Category
- Category C - Consult healthcare provider
Lactation Safety
- Use with caution, consult healthcare provider
Drug Interactions
- MAO inhibitors
- Tricyclic antidepressants
Overdose Symptoms
- Severe dizziness
- Tremors
- Seizures
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Readily absorbed from nasal mucosa
- Distribution: Distributed into systemic circulation
- Metabolism: Hepatic metabolism
- Excretion: Renal excretion
Precautions
- Do not exceed recommended dosage
- Avoid prolonged use
Warnings
- Use with caution in patients with heart conditions
Others
- Xylometazoline hydrochloride is for topical nasal use only.