Zoledronic Acid [For hypercalcemia]
Generic Details
Generic Name
Zoledronic Acid for Hypercalcemia
Other Names
- Zoledronate
Drug Class
- Bisphosphonate
Chemical Formula
C5H10N2O7P2
Molecular Weight
272.09 g/mol
Mechanism of Action
- Inhibits bone resorption by targeting osteoclasts
Indications
- Hypercalcemia of malignancy
Common Dosage Forms
- Injection
Typical Dosage
- 4 mg as a single intravenous infusion over at least 15 minutes
Pediatric Dosage
- Not established
Geriatric Dosage
- No adjustment required unless renal function is compromised
Side Effects
- Flu-like symptoms
- Fatigue
- Nausea
- Hypocalcemia
- Renal impairment
Contraindications
- Hypersensitivity to bisphosphonates
- Severe renal impairment
- Pregnancy
Pregnancy Category
- Category D - Positive evidence of risk
Lactation Safety
- Excretion in breast milk unknown; may consider alternatives
Drug Interactions
- Aminoglycosides
- Loop diuretics
- NSAIDs
Overdose Symptoms
- Hypocalcemia
- Hypophosphatemia
- Hypomagnesemia
Antidote for Overdose
- Calcium gluconate for hypocalcemia
Storage Conditions
- Store at controlled room temperature (15-30°C)
Pharmacokinetics
- Absorption: Not applicable as it is administered intravenously
- Distribution: Binds strongly to bone tissue
- Metabolism: Limited metabolism
- Excretion: Primarily renally excreted unchanged
Precautions
- Monitor renal function before each dose
- Ensure adequate hydration
Warnings
- May cause renal toxicity
- Osteonecrosis of the jaw