Ivabradine
Generic Details
Generic Name
Ivabradine
Other Names
- Corlanor
- Procoralan
Drug Class
- Cardiovascular Agent
- Selective If Inhibitor
Chemical Formula
C27H36N2O5S
Molecular Weight
504.66 g/mol
Mechanism of Action
- Inhibition of If current in the sinoatrial node
Indications
- Chronic stable angina pectoris
- Heart failure with reduced ejection fraction
Common Dosage Forms
- Tablet
Typical Dosage
- 5 mg or 7.5 mg twice daily with meals
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Dose adjustment may be required based on individual patient response
Side Effects
- Bradycardia
- Phosphenes (visual brightness)
- Atrial fibrillation
- Blood pressure decrease
Contraindications
- Acute decompensated heart failure
- Resting heart rate <60 bpm
- Sick sinus syndrome
- Severe hepatic impairment
Pregnancy Category
- Not recommended
Lactation Safety
- Limited data available; use with caution
Drug Interactions
- Simvastatin
- Verapamil
- Diltiazem
- Ciclosporin
- Clarithromycin
Overdose Symptoms
- Severe bradycardia
- Hypotension
- Atrioventricular block
Antidote for Overdose
- There is no specific antidote; treatment is symptomatic and supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Highly distributed in tissues, mainly metabolized by CYP3A4
- Metabolism: Metabolized in the liver
- Excretion: Excreted in feces and urine
Precautions
- Patients with conduction disorders
- Patients with liver impairment
Warnings
- May cause luminous phenomena
- May cause bradycardia
- Regular heart rate monitoring is recommended
Others
- May be used in combination with beta-blockers for angina management