Gemifloxacin
Generic Details
Generic Name
Gemifloxacin
Other Names
- Factive
Drug Class
- Fluoroquinolone Antibiotic
Chemical Formula
C18H20FN5O4
Molecular Weight
392.38 g/mol
Mechanism of Action
- Inhibits bacterial DNA gyrase and topoisomerase IV enzymes
Indications
- Acute bacterial exacerbations of chronic bronchitis
- Community-acquired pneumonia
Common Dosage Forms
- Tablet
Typical Dosage
- 320 mg once daily for 5 to 7 days
Pediatric Dosage
- Safety and efficacy not established in children under 18 years
Geriatric Dosage
- No dosage adjustment necessary
Side Effects
- Nausea
- Diarrhea
- Headache
- Insomnia
- Dizziness
Contraindications
- Hypersensitivity to gemifloxacin or other quinolone antibiotics
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution, excretion in breast milk is unknown
Drug Interactions
- Avoid concurrent use with multivitamins/minerals containing calcium, magnesium, aluminum, or iron
Overdose Symptoms
- Hypotension
- Confusion
- Seizures
Antidote for Overdose
- No specific antidote, manage symptoms and provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributed widely in body tissues
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Caution in patients with history of seizures
- Monitor for signs of tendinitis or tendon rupture
Warnings
- May cause Clostridium difficile-associated diarrhea