Tioconazole

Generic Details

Generic Name

Tioconazole

Other Names

  • Vagistat-1
  • Monistat
  • Trosyd

Drug Class

  • Antifungal

Chemical Formula

C16H13Cl4N3S

Molecular Weight

479.161 g/mol

Mechanism of Action

  • Inhibits ergosterol synthesis in fungal cell membranes

Indications

  • Vulvovaginal candidiasis (yeast infection)

Common Dosage Forms

  • Vaginal cream
  • Vaginal ointment
  • Vaginal suppository

Typical Dosage

  • 1 full applicator (300 mg) intravaginally for 1 day

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Use with caution due to potential age-related decrease in liver or renal function

Side Effects

  • Burning
  • Itching
  • Irritation at application site
  • Abdominal pain

Contraindications

  • Hypersensitivity to tioconazole or other imidazoles

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect

Lactation Safety

  • Limited data available, use caution

Drug Interactions

  • No significant interactions reported

Overdose Symptoms

  • No specific overdose symptoms reported

Antidote for Overdose

  • No specific antidote, symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed after intravaginal administration
  • Distribution: Not extensively characterized
  • Metabolism: Hepatic metabolism
  • Excretion: Primarily renal excretion

Precautions

  • Avoid contact with eyes
  • Avoid sexual activity during treatment

Warnings

  • For vaginal use only
  • Consult healthcare provider before use in pregnancy or lactation

Others

  • May weaken latex condoms and diaphragms