Besifloxacin
Generic Details
Generic Name
Besifloxacin
Other Names
- Besivance
- Besivance Ophthalmic Suspension
Drug Class
- Fluoroquinolone Antibiotic
Chemical Formula
C19H21ClFN3O3
Molecular Weight
413.841 g/mol
Mechanism of Action
- Inhibition of bacterial DNA gyrase and topoisomerase IV
Indications
- Bacterial conjunctivitis
Common Dosage Forms
- Ophthalmic suspension
Typical Dosage
- Instill 1 drop into affected eye(s) 3 times a day
Pediatric Dosage
- Safety and efficacy not established in children under 1 year of age
Geriatric Dosage
- Adjust dosage as needed based on individual response and renal function
Side Effects
- Burning or stinging
- Eye redness
- Eye pain
- Blurry vision
- Dry eye
- Taste changes
Contraindications
- Hypersensitivity to besifloxacin or other quinolones
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Use caution; may excrete into breast milk
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- No specific overdose symptoms reported
Antidote for Overdose
- No specific antidote; symptomatic and supportive treatment
Storage Conditions
- Store at controlled room temperature between 15°C to 25°C (59°F to 77°F)
Pharmacokinetics
- Absorption: Minimal systemic absorption after ocular administration
- Distribution: Limited distribution in ocular tissues
- Metabolism: Metabolized to inactive compounds
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Avoid contact lens wear during treatment
Warnings
- For ophthalmic use only; not for injection or oral ingestion