Fluorometholone + Tetrahydrozoline
Generic Details
Generic Name
Fluorometholone-Tetrahydrozoline
Other Names
- Fluorometholone-Tetrahydrozoline Ophthalmic Suspension
- FML-T
Drug Class
- Corticosteroid
- Ophthalmic Decongestant
Chemical Formula
C22H29FO4.C13H16N2
Molecular Weight
Mechanism of Action
- Fluorometholone: Anti-inflammatory
- Tetrahydrozoline: Vasoconstrictor
Indications
- Allergic conjunctivitis
- Seasonal allergic rhinitis with ocular symptoms
- Ophthalmic redness
Common Dosage Forms
- Ophthalmic suspension
Typical Dosage
- Apply 1 to 2 drops in the affected eye(s) 2 to 4 times daily
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- May require lower doses due to potential systemic absorption
Side Effects
- Blurred vision
- Burning or stinging sensation in the eye
- Increased intraocular pressure
- Eye irritation
Contraindications
- Hypersensitivity to fluorometholone, tetrahydrozoline, or any component of the formulation
- Untreated eye infections
- Glaucoma
Pregnancy Category
- C - Use with caution
Lactation Safety
- Use with caution
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs) can potentiate the vasoconstrictive effect of tetrahydrozoline
Overdose Symptoms
- Severe headache
- Increased blood pressure
- Tremors
Antidote for Overdose
- Supportive care and symptom management
Storage Conditions
- Store at room temperature between 15-30°C (59-86°F)
Pharmacokinetics
- Absorption: Systemic absorption may occur through the nasal mucosa and conjunctiva
- Distribution: Fluorometholone is extensively bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in urine
Precautions
- Avoid prolonged use to prevent potential ocular complications
- Monitor for increased intraocular pressure
Warnings
- Do not use for longer than 10 days without medical supervision
- Prolonged use may lead to glaucoma or cataracts