Cinchocaine + Hydrocortisone + Neomycin + Esculin

Generic Details

Generic Name

Cinchocaine-Hydrocortisone-Neomycin-Esculin

Other Names

  • Anusol HC

Drug Class

  • Topical corticosteroid and antibiotic combination

Chemical Formula

Molecular Weight

Mechanism of Action

  • Cinchocaine (Dibucaine) - Local anesthetic
  • Hydrocortisone - Corticosteroid with anti-inflammatory properties
  • Neomycin - Antibiotic that treats or prevents bacterial infections
  • Esculin - Biologically active constituent with anti-inflammatory and vasoconstrictor effects

Indications

  • Hemorrhoids
  • Anal itching
  • Anal fissures

Common Dosage Forms

  • Topical cream
  • Suppository

Typical Dosage

  • Apply a thin layer of cream to the affected area up to 3 to 4 times daily
  • Insert one suppository into the rectum once or twice daily

Pediatric Dosage

  • Use under medical supervision

Geriatric Dosage

  • Use with caution due to increased risk of skin thinning and bruising

Side Effects

  • Skin irritation
  • Burning sensation
  • Itching
  • Allergic reactions

Contraindications

  • Hypersensitivity to any of the components
  • Viral or fungal infections in the treated area
  • Tuberculosis
  • Perianal itching without any inflammation

Pregnancy Category

  • Use only if benefits outweigh risks, consult healthcare provider

Lactation Safety

  • Use cautiously, avoid application on the breast area before breastfeeding

Drug Interactions

  • Unknown interactions, consult healthcare provider

Overdose Symptoms

  • Unlikely with topical use, potential for increased side effects if ingested

Antidote for Overdose

  • Symptomatic treatment if necessary

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Absorption into the bloodstream is minimal due to topical application
  • Distribution: Localized distribution at the application site
  • Metabolism: Metabolized locally at the application site
  • Excretion: Excreted mainly through feces

Precautions

  • Avoid contact with eyes, mouth, or open wounds
  • Do not use for long periods without medical supervision
  • Discontinue use if irritation occurs

Warnings

  • Not for ophthalmic use
  • Do not exceed recommended dosage or duration of use

Others

  • Always consult a healthcare provider before use.