Vinorelbine Tartrate
Generic Details
Generic Name
Vinorelbine Tartrate
Other Names
- Navelbine
Drug Class
- Antineoplastic
Chemical Formula
C45H54N4O8
Molecular Weight
778.94 g/mol
Mechanism of Action
- Vinorelbine interferes with microtubule assembly, leading to cell cycle arrest and apoptosis.
Indications
- Non-small cell lung cancer
- Breast cancer
Common Dosage Forms
- Injection
Typical Dosage
- 30-35 mg/m² once a week
Pediatric Dosage
- Limited data available; individualized dosing required
Geriatric Dosage
- May require dose adjustment based on renal function
Side Effects
- Bone marrow suppression
- Nausea/vomiting
- Fatigue
- Peripheral neuropathy
Contraindications
- Hypersensitivity to vinorelbine or any component of the formulation
- Severe hepatic impairment
Pregnancy Category
- D
Lactation Safety
- Limited data available; caution advised
Drug Interactions
- Strong CYP3A4 inhibitors may increase vinorelbine levels
Overdose Symptoms
- Severe neutropenia
- Severe gastrointestinal toxicity
Antidote for Overdose
- Supportive care and hematopoietic growth factors
Storage Conditions
- Store at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: Well absorbed after intravenous administration
- Distribution: Extensively distributed in tissues
- Metabolism: Primarily hepatic
- Excretion: Mainly through urine
Precautions
- Monitor blood counts regularly
- Use with caution in patients with hepatic or renal impairment
Warnings
- Risk of myelosuppression
- Neurologic toxicity