Betamethasone + Clotrimazole

Generic Details

Generic Name

Betamethasone-Clotrimazole

Other Names

  • Lotrisone

Drug Class

  • Topical corticosteroid and antifungal combination

Chemical Formula

C22H29FO5 - C22H17ClN2

Molecular Weight

504.51 g/mol - 344.84 g/mol

Mechanism of Action

  • Betamethasone: suppresses inflammation by inhibiting the migration of polymorphonuclear leukocytes and reducing capillary permeability.
  • Clotrimazole: disrupts fungal cell wall synthesis by inhibiting the enzyme cytochrome P450.

Indications

  • Topical treatment of fungal infections complicated by inflammatory manifestations

Common Dosage Forms

  • Cream
  • Lotion

Typical Dosage

  • Apply a thin layer to the affected area twice daily for up to 2 weeks.

Pediatric Dosage

  • Use under pediatrician's guidance.

Geriatric Dosage

  • Use with caution and under medical supervision in the elderly.

Side Effects

  • Burning
  • Itching
  • Dryness
  • Redness
  • Folliculitis
  • Hypopigmentation
  • Perioral dermatitis

Contraindications

  • Hypersensitivity to any component of the product

Pregnancy Category

  • Category C - Consult healthcare provider before use.

Lactation Safety

  • Use with caution and under medical guidance.

Drug Interactions

  • No significant interactions reported.

Overdose Symptoms

  • Unlikely with topical use, but prolonged use can lead to systemic manifestations of corticosteroids.

Antidote for Overdose

  • Discontinue use and seek medical advice.

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Topical application leads to minimal systemic absorption.
  • Distribution: Not well described.
  • Metabolism: Hepatic metabolism for both components.
  • Excretion: Primarily renal for clotrimazole and urinary and biliary for betamethasone.

Precautions

  • Avoid contact with eyes.
  • Not for use on large areas of the body for an extended period.

Warnings

  • Do not use for longer than prescribed.
  • Discontinue if irritation or sensitization occurs.

Others

  • Avoid covering the treated area with bandages or dressings unless directed by a healthcare provider.