Linagliptin + Metformin Hydrochloride

Generic Details

Generic Name

Linagliptin-Metformin Hydrochloride

Other Names

  • Linagliptin-Metformin HCl

Drug Class

  • Antidiabetic Combination

Chemical Formula

C25H30N8O2.C4H11N.HCl

Molecular Weight

633.11 g/mol

Mechanism of Action

  • Linagliptin - DPP-4 Inhibitor
  • Metformin - Decreases Glucose Production in the Liver, Improves Insulin Sensitivity

Indications

  • Type 2 Diabetes Mellitus

Common Dosage Forms

  • Tablet

Typical Dosage

  • Take as directed by the physician

Pediatric Dosage

  • Safety and efficacy not established in pediatric patients

Geriatric Dosage

  • Adjust dose based on renal function

Side Effects

  • Hypoglycemia
  • Nausea
  • Diarrhea
  • Headache
  • Upper Respiratory Tract Infection

Contraindications

  • Hypersensitivity to any component
  • Severe renal impairment
  • Acute or chronic metabolic acidosis

Pregnancy Category

  • Category B

Lactation Safety

  • Use with caution while breastfeeding

Drug Interactions

  • Caution with drugs causing hyperglycemia or hypoglycemia
  • Alcohol may potentiate metformin effect on lactate

Overdose Symptoms

  • Lactic acidosis
  • Hypoglycemia

Antidote for Overdose

  • Hemodialysis (for metformin)

Storage Conditions

  • Store at room temperature (15-30°C)

Pharmacokinetics

  • Absorption: Linagliptin - Rapid and complete
  • Distribution: Metformin - Widely distributed
  • Metabolism: Primarily hepatic for linagliptin
  • Excretion: Renal for both components

Precautions

  • Monitor renal function regularly
  • Assess for signs of lactic acidosis

Warnings

  • Risk of lactic acidosis
  • Can cause pancreatitis

Others

  • Always take with meals to reduce gastrointestinal side effects