Dasatinib
Generic Details
Generic Name
Dasatinib
Other Names
- Sprycel
Drug Class
- Tyrosine Kinase Inhibitor
Chemical Formula
C22H28ClN7O2S
Molecular Weight
488.02 g/mol
Mechanism of Action
- Inhibits BCR-ABL tyrosine kinase
- Inhibits SRC family kinases
Indications
- Chronic Myeloid Leukemia (CML)
- Acute Lymphoblastic Leukemia (ALL)
Common Dosage Forms
- Tablet
Typical Dosage
- 100 mg to 140 mg orally once daily
Pediatric Dosage
- Dosage based on body weight and guidelines
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Nausea
- Fatigue
- Diarrhea
- Headache
- Myelosuppression
Contraindications
- Hypersensitivity to Dasatinib
Pregnancy Category
- D
Lactation Safety
- Unsafe, may harm the baby
Drug Interactions
- Strong CYP3A4 inhibitors or inducers
- Grapefruit juice
Overdose Symptoms
- Severe myelosuppression
- Fluid retention
Antidote for Overdose
- No specific antidote, manage symptoms
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapid absorption with a bioavailability of approximately 30%
- Distribution: Highly bound to plasma protein
- Metabolism: Primarily hepatic via CYP3A4
- Excretion: Mainly via feces
Precautions
- Monitor blood counts regularly
- Cardiac monitoring for QT prolongation
Warnings
- Risk of myelosuppression and bleeding events
- Fluid retention and pulmonary arterial hypertension
Others
- Regular monitoring of liver function tests during treatment