Aluminium Oxide + Magnesium Trisilicate
Generic Details
Generic Name
Aluminium Oxide Magnesium Trisilicate
Other Names
- Alumina
- Magnesium Trisilicate
Drug Class
- Antacid
Chemical Formula
Al2MgO8Si2
Molecular Weight
258.305 g/mol
Mechanism of Action
- Neutralizes stomach acid
- Forms a protective barrier in the stomach lining
Indications
- Acid indigestion
- Heartburn
- Gastric and duodenal ulcers
- Dyspepsia
Common Dosage Forms
- Tablet
- Suspension
Typical Dosage
- 250-500 mg orally 4 times a day after meals and at bedtime
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Dose adjustment may be needed; consult healthcare provider
Side Effects
- Constipation
- Diarrhea
- Abdominal discomfort
- Hypophosphatemia
Contraindications
- Hypersensitivity to ingredients
- Severe kidney disease
- Aluminum toxicity
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Compatible with breastfeeding; amounts excreted into breast milk are minimal
Drug Interactions
- Tetracycline antibiotics
- Fluoroquinolone antibiotics
- Digoxin
Overdose Symptoms
- Severe constipation
- Altered mental status
- Muscle weakness
Antidote for Overdose
- Discontinue the medication
- Provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Poorly absorbed from the gastrointestinal tract
- Distribution: Does not distribute significantly into tissues
- Metabolism: Not significantly metabolized in the body
- Excretion: Primarily excreted unchanged in the feces
Precautions
- Monitor phosphate levels with long-term use
- Avoid taking other medications within 2 hours of aluminium oxide magnesium trisilicate
Warnings
- May interfere with the absorption of other medications
- Long-term use may lead to aluminum toxicity
Others
- Consult healthcare provider before use in patients with renal impairment