Acyclovir (Ophthalmic)

Generic Details

Generic Name

Acyclovir-ophthalmic

Other Names

  • Acyclovir eye ointment

Drug Class

  • Antiviral agent

Chemical Formula

C8H11N5O3

Molecular Weight

225.2 g/mol

Mechanism of Action

  • Inhibits viral DNA replication by competing with deoxyguanosine triphosphate for viral DNA polymerase

Indications

  • Herpes simplex keratitis
  • Herpes zoster ophthalmicus

Common Dosage Forms

  • Eye ointment

Typical Dosage

  • Apply a small amount (1/2 inch ribbon) into the conjunctival sac five times per day

Pediatric Dosage

  • As per physician's guidance

Geriatric Dosage

  • Dosage adjustments may be needed; consult healthcare provider

Side Effects

  • Blurred vision
  • Burning or stinging
  • Redness or irritation of the eye

Contraindications

  • Hypersensitivity to acyclovir or any component of the formulation

Pregnancy Category

  • Category B - No evidence of risk in humans

Lactation Safety

  • Limited data; consult healthcare provider

Drug Interactions

  • No significant drug interactions reported with ophthalmic use

Overdose Symptoms

  • Unlikely with ophthalmic use

Antidote for Overdose

  • N/A

Storage Conditions

  • Store at room temperature (15-25°C)

Pharmacokinetics

  • Absorption: Minimal systemic absorption after ophthalmic use
  • Distribution: Limited distribution in ocular tissues
  • Metabolism: Does not undergo hepatic metabolism
  • Excretion: Mainly excreted unchanged in urine

Precautions

  • Avoid contact with the tip of the ointment tube to prevent contamination

Warnings

  • For ophthalmic use only
  • Do not touch the eye with the tip of the tube

Others

  • Do not wear contact lenses while using the ointment