Dextromethorphan + Phenylephrine + Triprolidine
Generic Details
Generic Name
Dextromethorphan-Phenylephrine-Triprolidine
Other Names
- DPT
Drug Class
- Antitussive
- Decongestant
- Antihistamine
Chemical Formula
Molecular Weight
Mechanism of Action
- Dextromethorphan acts on the cough center in the brain to suppress the cough reflex.
- Phenylephrine constricts blood vessels in the nasal passages, helping to relieve nasal congestion.
- Triprolidine blocks the action of histamine, reducing allergy symptoms such as sneezing and itching.
Indications
- Cough
- Nasal congestion
- Allergic rhinitis
Common Dosage Forms
- Syrup
- Tablet
- Capsule
Typical Dosage
- Adults: 1-2 tablets every 4-6 hours
- Children: Consult a healthcare provider for appropriate dosage.
Pediatric Dosage
- Prescribed by a healthcare provider based on age and weight.
Geriatric Dosage
- Lower starting doses may be recommended for the elderly.
Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Nausea
- Constipation
Contraindications
- Hypersensitivity to any component
- Severe hypertension
- Severe heart disease
Pregnancy Category
- C - Consult healthcare provider before use
Lactation Safety
- Caution advised, consult healthcare provider
Drug Interactions
- MAO inhibitors
- Sedatives
- Antihypertensives
Overdose Symptoms
- Severe drowsiness
- Confusion
- Seizures
Antidote for Overdose
- Supportive care, activated charcoal if appropriate
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract.
- Distribution: Distributed to various body tissues.
- Metabolism: Metabolized in the liver.
- Excretion: Excreted mainly in the urine.
Precautions
- Avoid concurrent use of other cough and cold medications.
- Use caution when driving or operating machinery due to potential drowsiness.
Warnings
- Do not exceed recommended dosage.
- Consult healthcare provider for prolonged use.
Others
- Do not use this medication to sedate a child.