Ipratropium Bromide
Generic Details
Generic Name
Ipratropium Bromide
Other Names
- Atrovent
Drug Class
- Anticholinergic
Chemical Formula
C20H30NO3Br
Molecular Weight
412.36 g/mol
Mechanism of Action
- Blocks muscarinic acetylcholine receptors, resulting in bronchodilation
Indications
- Chronic obstructive pulmonary disease (COPD)
- Asthma
Common Dosage Forms
- Inhalation aerosol
- Nebulizer solution
Typical Dosage
- 2 inhalations (42 mcg total dose) four times a day
Pediatric Dosage
- 0.25-0.5 mg administered three to four times a day
Geriatric Dosage
- Dose adjustment may be required
Side Effects
- Dry mouth
- Headache
- Cough
- Nausea
- Dizziness
Contraindications
- Hypersensitivity to ipratropium or atropine
Pregnancy Category
- C
Lactation Safety
- Compatible
Drug Interactions
- Beta-agonists
- Other anticholinergic drugs
Overdose Symptoms
- Blurred vision
- Nausea
- Dizziness
- Headache
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Well absorbed from the lungs
- Distribution: Wide distribution in the body
- Metabolism: Hepatic metabolism
- Excretion: Primarily renal excretion
Precautions
- Avoid spraying into eyes
Warnings
- Not for acute bronchospasm