Ketotifen Fumarate (Ophthalmic)
Generic Details
Generic Name
Ketotifen Fumarate Ophthalmic
Other Names
- Ketotifen ophthalmic solution
- Ketotifen eye drops
Drug Class
- Antihistamine
- Mast cell stabilizer
Chemical Formula
C19H19NOS
Molecular Weight
309.42 g/mol
Mechanism of Action
- Blocks H1 histamine receptors
- Stabilizes mast cells
Indications
- Allergic conjunctivitis
- Seasonal allergic rhinitis
Common Dosage Forms
- Ophthalmic solution
Typical Dosage
- 1 drop in the affected eye(s) twice daily
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Adjust dosage based on individual patient needs
Side Effects
- Burning sensation in the eyes
- Stinging
- Dry eyes
- Headache
Contraindications
- Hypersensitivity to ketotifen or any component of the formulation
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus
Lactation Safety
- Use with caution, potential risk to the infant
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Excessive drowsiness
- Confusion
- Weakness
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at controlled room temperature between 15-30°C (59-86°F)
Pharmacokinetics
- Absorption: Minimal systemic absorption after ophthalmic administration
- Distribution: Not well defined due to localized action
- Metabolism: Hepatic metabolism
- Excretion: Primarily renal excretion
Precautions
- Do not touch the dropper tip to any surface to avoid contamination
Warnings
- Discontinue use if irritation or allergic reaction occurs
Others
- Do not use contact lenses while using ketotifen ophthalmic solution