Methylprednisolone
Generic Details
Generic Name
Methylprednisolone
Other Names
- Medrol
- Solu-Medrol
- Depo-Medrol
Drug Class
- Corticosteroid
Chemical Formula
C22H30O5
Molecular Weight
374.48 g/mol
Mechanism of Action
- Methylprednisolone is a synthetic glucocorticoid that exerts anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors in target cells.
Indications
- Allergic disorders
- Dermatologic diseases
- Rheumatic disorders
- Endocrine disorders
- Respiratory diseases
- Hematologic disorders
- Autoimmune diseases
Common Dosage Forms
- Tablet
- Injection
- Cream
- Ointment
Typical Dosage
- 4-48 mg per day depending on the condition being treated
Pediatric Dosage
- Dosage varies based on the child's weight and the condition being treated
Geriatric Dosage
- Lower doses are often recommended for elderly patients
Side Effects
- Fluid retention
- Hypertension
- Hyperglycemia
- Peptic ulcers
- Mood changes
- Insomnia
- Immunosuppression
Contraindications
- Systemic fungal infections
- Live vaccines
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Generally considered compatible with breastfeeding
Drug Interactions
- NSAIDs
- Warfarin
- Insulin
- Ketoconazole
Overdose Symptoms
- Severe headache
- Dizziness
- Blurred vision
- Weakness
- Swelling
Antidote for Overdose
- No specific antidote, treatment involves symptomatic and supportive measures
Storage Conditions
- Store at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapidly and well-absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body and crosses the placenta
- Metabolism: Mainly hepatic via CYP3A4
- Excretion: Primarily excreted in urine as metabolites
Precautions
- Monitor for signs of infection
- Avoid abrupt discontinuation
- Use caution in patients with diabetes or glaucoma
Warnings
- Long-term use may lead to adrenal suppression
- May mask symptoms of infection