Prednisolone Acetate
Generic Details
Generic Name
Prednisolone Acetate
Other Names
- Pred Forte
- Omnipred
Drug Class
- Corticosteroid
Chemical Formula
C23H30O6
Molecular Weight
402.48 g/mol
Mechanism of Action
- Anti-inflammatory
- Immunosuppressant
Indications
- Allergic reactions
- Ophthalmic inflammation
- Rheumatic disorders
- Skin conditions
Common Dosage Forms
- Ophthalmic suspension
- Ophthalmic ointment
Typical Dosage
- 1 to 2 drops in the affected eye(s) every hour
Pediatric Dosage
- Use under pediatrician supervision
Geriatric Dosage
- May require lower doses due to increased risk of side effects
Side Effects
- Blurred vision
- Eye irritation
- Increased intraocular pressure
- Headache
Contraindications
- Hypersensitivity to prednisolone or any component of the formulation
Pregnancy Category
- C - Use with caution
Lactation Safety
- Compatible with breastfeeding, but use caution
Drug Interactions
- May interact with certain anticoagulants, antidiabetic drugs, and NSAIDs
Overdose Symptoms
- Severe headache
- Blurred vision
- Increased intraocular pressure
Antidote for Overdose
- No specific antidote, treatment is symptomatic
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light
Pharmacokinetics
- Absorption: Absorbed systemically when used ophthalmically
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted renally
Precautions
- Monitor intraocular pressure during prolonged use
Warnings
- Not for use in viral infections of the eye without concomitant antiviral therapy
Others
- Avoid contact with contact lenses while using the ophthalmic formulations.