Bisoprolol Hemifumarate
Generic Details
Generic Name
Bisoprolol-hemifumarate
Other Names
- Bisoprolol fumarate
Drug Class
- Beta-blocker
Chemical Formula
C18H31NO4
Molecular Weight
325.45 g/mol
Mechanism of Action
- Selective beta-1 adrenergic receptor antagonist
Indications
- Hypertension
- Angina
- Heart failure
Common Dosage Forms
- Tablet
Typical Dosage
- 5-10 mg once daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Lower initial doses may be necessary in the elderly
Side Effects
- Bradycardia
- Hypotension
- Fatigue
- Dizziness
- Headache
Contraindications
- Sinus bradycardia
- Heart block greater than first degree
- Cardiogenic shock
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- May enhance the hypoglycemic effects of insulin and oral antidiabetic agents
Overdose Symptoms
- Bradycardia
- Hypotension
- Cardiac insufficiency
Antidote for Overdose
- Atropine may be administered
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed from the gastrointestinal tract
- Distribution: Extensively distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Use with caution in patients with bronchospastic diseases
- Abrupt withdrawal should be avoided
Warnings
- May mask the symptoms of hypoglycemia in diabetic patients
Others
- Can be used in conjunction with other antihypertensive agents for additive effects