Tenofovir Alafenamide

Generic Details

Generic Name

Tenofovir-Alafenamide

Other Names

  • TAF

Drug Class

  • Antiretroviral

Chemical Formula

C21H29N6O5P

Molecular Weight

476.47 g/mol

Mechanism of Action

  • Tenofovir-Alafenamide is a prodrug of tenofovir, which inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5′-triphosphate, leading to chain termination.

Indications

  • HIV-1 infection
  • Chronic hepatitis B

Common Dosage Forms

  • Tablet
  • Oral solution

Typical Dosage

  • One tablet (25 mg) once daily with food for HIV-1 infection
  • One tablet (25 mg) once daily for chronic hepatitis B

Pediatric Dosage

  • Dosage varies based on weight and age, consulting a healthcare provider is recommended

Geriatric Dosage

  • No specific dosage adjustment is required based on age alone; however, renal function should be monitored

Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Fatigue
  • Elevations in blood creatinine

Contraindications

  • Hypersensitivity to Tenofovir-Alafenamide

Pregnancy Category

  • Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women

Lactation Safety

  • Limited data suggests minimal risk while breastfeeding, monitor the infant for gastrointestinal disturbances

Drug Interactions

  • Tenofovir-Alafenamide may interact with drugs that affect renal function or are nephrotoxic, such as NSAIDs or certain antibiotics

Overdose Symptoms

  • Acute renal failure
  • Fanconi syndrome

Antidote for Overdose

  • There is no specific antidote, treatment is supportive and based on symptoms

Storage Conditions

  • Store at room temperature between 20-25°C (68-77°F)
  • Protect from light and moisture

Pharmacokinetics

  • Absorption: Well absorbed following oral administration
  • Distribution: Distributed to plasma and peripheral blood mononuclear cells
  • Metabolism: Metabolized in the liver to tenofovir
  • Excretion: Primarily excreted in the urine

Precautions

  • Monitor renal function regularly, especially in patients with preexisting renal impairment

Warnings

  • May cause renal impairment, osteomalacia, and exacerbation of hepatitis B upon discontinuation

Others

  • Tenofovir-Alafenamide has demonstrated similar efficacy to tenofovir disoproxil fumarate but with lower renal and bone toxicity