Bisoprolol Fumarate + Hydrochlorothiazide

Generic Details

Generic Name

Bisoprolol-Fumarate-Hydrochlorothiazide

Other Names

Bisoprolol HCTZ

Drug Class

Beta-blocker with thiazide diuretic

Chemical Formula

C18H31NO4.C7H8ClN3O4S2

Molecular Weight

681.68 g/mol

Mechanism of Action

Bisoprolol reduces heart rate and blood pressure by blocking beta receptors. Hydrochlorothiazide promotes diuresis by inhibiting sodium reabsorption.

Indications

Hypertension
Congestive heart failure

Common Dosage Forms

Tablet

Typical Dosage

5mg/6.25mg to 10mg/6.25mg once daily

Pediatric Dosage

Not established

Geriatric Dosage

Dosage adjustments may be required

Side Effects

Dizziness
Fatigue
Hypotension
Increased urination
Electrolyte imbalances

Contraindications

Bradycardia
Severe hepatic impairment
Severe renal impairment

Pregnancy Category

C - Bisoprolol
C - Hydrochlorothiazide

Lactation Safety

Limited data available, caution advised

Drug Interactions

NSAIDs
Lithium
Digitalis glycosides

Overdose Symptoms

Severe hypotension
Bradycardia
Electrolyte abnormalities

Antidote for Overdose

Intravenous fluids
Atropine for bradycardia

Storage Conditions

Store at room temperature away from moisture and heat

Pharmacokinetics

Absorption: Well absorbed orally
Distribution: Bisoprolol: Widely distributed, Hydrochlorothiazide: Crosses the placenta and enters breast milk
Metabolism: Bisoprolol: Hepatic (CYP2D6), Hydrochlorothiazide: Minimal metabolism
Excretion: Renal

Precautions

Caution in patients with asthma or COPD due to beta-blocker component
Monitor electrolytes periodically

Warnings

May cause fetal harm if used during pregnancy
Avoid abrupt withdrawal to prevent rebound hypertension

Others

Combination therapy to address both hypertension and heart failure