Allylestrenol
Generic Details
Generic Name
Allylestrenol
Other Names
- Allyloestrenol
- Allyouestrenol
Drug Class
- Progestogen
Chemical Formula
C21H32O
Molecular Weight
300.48 g/mol
Mechanism of Action
- Progestational activity
Indications
- Threatened and recurrent miscarriage
- Menstrual disorders
- Infertility
Common Dosage Forms
- Tablet
- Oral solution
Typical Dosage
- 5-10 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Use with caution, may require dosage adjustment
Side Effects
- Nausea
- Vomiting
- Breast tenderness
- Headache
- Weight changes
Contraindications
- Pregnancy
- Breastfeeding
- Undiagnosed vaginal bleeding
- Hypersensitivity to progestogens
Pregnancy Category
- Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Possible interaction with anticonvulsants, anticoagulants, and certain antibiotics
Overdose Symptoms
- Nausea
- Vomiting
- Dizziness
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Protein-bound, crosses the placenta and enters breast milk
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in the urine
Precautions
- Monitor for signs of thromboembolism
- Monitor liver function during treatment
Warnings
- Increased risk of thromboembolism
- May mask certain medical conditions
Others
- Allylestrenol should be used under the supervision of a healthcare provider