Cilnidipine

Generic Details

Generic Name

Cilnidipine

Other Names

  • Cilnidipine Hydrochloride

Drug Class

  • Calcium Channel Blocker

Chemical Formula

C27H28N2O6

Molecular Weight

492.52 g/mol

Mechanism of Action

  • Blocks L-type calcium channels in smooth muscles and cardiac muscle, leading to vasodilation and reduced blood pressure

Indications

  • Hypertension

Common Dosage Forms

  • Tablet

Typical Dosage

  • 5-10 mg once daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Lower initial doses may be required in the elderly

Side Effects

  • Peripheral edema
  • Headache
  • Flushing
  • Dizziness

Contraindications

  • Hypersensitivity to cilnidipine
  • Severe hypotension

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

  • Not recommended during breastfeeding

Drug Interactions

  • CYP3A4 inhibitors such as ketoconazole may increase cilnidipine levels

Overdose Symptoms

  • Excessive hypotension
  • Bradycardia

Antidote for Overdose

  • Intravenous calcium infusion may be used to counteract the effects of overdose

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly and well absorbed after oral administration
  • Distribution: Highly protein-bound (99%)
  • Metabolism: Metabolized in the liver
  • Excretion: Primarily excreted in the urine

Precautions

  • Caution in patients with hepatic impairment

Warnings

  • Avoid sudden discontinuation as it may lead to rebound hypertension

Others

  • Cilnidipine may provide better renal protection compared to other calcium channel blockers