Gentamicin Sulfate (Ophthalmic)
Generic Details
Generic Name
Gentamicin Sulfate Ophthalmic
Other Names
- Gentamicin Eye Drops
- Gentamicin Ophthalmic Solution
Drug Class
- Aminoglycoside Antibiotic
Chemical Formula
C21H46N5O7
Molecular Weight
477.63 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit of susceptible bacteria.
Indications
- Bacterial Conjunctivitis
- Keratitis
- Corneal Ulcers
- Blepharitis
Common Dosage Forms
- Ophthalmic Solution
Typical Dosage
- 1-2 drops in the affected eye(s) every 4 hours
Pediatric Dosage
- As directed by a pediatrician
Geriatric Dosage
- Dose adjustment may be necessary in the elderly with renal impairment
Side Effects
- Burning/stinging in the eye
- Blurred vision
- Redness of the eye
- Allergic reactions
Contraindications
- Hypersensitivity to aminoglycosides
Pregnancy Category
- Category D - Positive evidence of risk
Lactation Safety
- Limited data available; caution advised
Drug Interactions
- Avoid concurrent use with other ototoxic or nephrotoxic drugs
Overdose Symptoms
- Severe dizziness
- Trouble breathing
- Nausea/vomiting
Antidote for Overdose
- No specific antidote; supportive care
Storage Conditions
- Store at controlled room temperature between 15°C to 25°C (59°F to 77°F)
Pharmacokinetics
- Absorption: Minimal systemic absorption through the eye
- Distribution: Limited distribution outside of the eye tissues
- Metabolism: Not extensively metabolized
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Avoid contact with soft contact lenses
- Not for injection into the eye
- Use with caution in patients with renal impairment
Warnings
- For topical ophthalmic use only
- Prolonged use may result in overgrowth of nonsusceptible organisms
Others
- Shake well before use
- Discard unused medication after the prescribed duration