Gentamicin Sulfate (Topical)
Generic Details
Generic Name
Gentamicin Sulfate Topical
Other Names
- Gentamicin cream
- Gentamicin ointment
Drug Class
- Aminoglycoside Antibiotic
Chemical Formula
C21H43N5O7
Molecular Weight
477.595 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
Indications
- Topical treatment of skin infections caused by susceptible bacteria
Common Dosage Forms
- Cream
- Ointment
Typical Dosage
- Apply a thin layer to the affected area 2-4 times daily
Pediatric Dosage
- Use with caution and as directed by a healthcare provider
Geriatric Dosage
- Use with caution and as directed by a healthcare provider
Side Effects
- Local irritation
- Allergic contact dermatitis
- Burning sensation
Contraindications
- Hypersensitivity to aminoglycosides
Pregnancy Category
- Category D - Positive evidence of risk
Lactation Safety
- Caution advised. Consult healthcare provider before use
Drug Interactions
- No significant drug interactions reported with topical use
Overdose Symptoms
- Unlikely with topical use
Antidote for Overdose
- N/A - Unlikely with topical use
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Minimal systemic absorption through intact skin
- Distribution: Limited distribution
- Metabolism: Not extensively metabolized
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Avoid contact with eyes and mucous membranes
Warnings
- Discontinue use if skin irritation occurs