Nabumetone
Generic Details
Generic Name
Nabumetone
Other Names
- Relafen
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C15H16O2
Molecular Weight
228.29 g/mol
Mechanism of Action
- Inhibits cyclooxygenase, resulting in decreased prostaglandin synthesis
Indications
- Osteoarthritis
- Rheumatoid arthritis
Common Dosage Forms
- Tablet
Typical Dosage
- 500-1000 mg once daily or divided into two doses
Pediatric Dosage
- Not recommended for children under 18 years
Geriatric Dosage
- Adjust dose based on renal function
Side Effects
- Gastrointestinal upset
- Ulcers
- Bleeding
- Hypersensitivity reactions
Contraindications
- History of allergic reactions to NSAIDs
- Active peptic ulcer disease
- Severe renal impairment
Pregnancy Category
- Category C - Avoid use in the third trimester
Lactation Safety
- Limited data - Caution advised
Drug Interactions
- Aspirin
- Warfarin
- ACE inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
- Drowsiness
- Seizures
Antidote for Overdose
- Activated charcoal
- Symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Widely distributed in the body
- Metabolism: Hepatic metabolism to active metabolite
- Excretion: Excreted in urine and feces
Precautions
- Monitor renal function
- Avoid in patients with a history of peptic ulcer disease
- Avoid in patients with heart failure
Warnings
- Increased risk of cardiovascular events and gastrointestinal bleeding
- Long-term use may increase the risk of renal toxicity
Others
- May take several weeks for full effects to be seen