Pirfenidone
Generic Details
Generic Name
Pirfenidone
Other Names
- Esbriet
Drug Class
- Antifibrotic
Chemical Formula
C12H11NO
Molecular Weight
185.22 g/mol
Mechanism of Action
- Antifibrotic, anti-inflammatory, and antioxidant properties
Indications
- Idiopathic pulmonary fibrosis (IPF)
- Progressive fibrosing interstitial lung diseases
Common Dosage Forms
- Tablet
Typical Dosage
- 801 mg three times a day with food
Pediatric Dosage
- Not recommended
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Nausea
- Fatigue
- Rash
- Dizziness
- Decreased appetite
Contraindications
- Hypersensitivity to pirfenidone
- Severe hepatic impairment
Pregnancy Category
- Category C
Lactation Safety
- Not recommended
Drug Interactions
- CYP1A2 inhibitors
- CYP1A2 inducers
- P-glycoprotein inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Dizziness
- Abdominal pain
Antidote for Overdose
- No specific antidote, manage symptoms
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapid and almost complete
- Distribution: Extensively distributed
- Metabolism: Primarily hepatic via CYP1A2
- Excretion: Mainly through urine (unchanged drug)
Precautions
- Monitor liver function tests
- Regular monitoring of renal function
Warnings
- Increased risk of photosensitivity reactions
- May cause liver enzyme elevations