Naftifine Hydrochloride

Generic Details

Generic Name

Naftifine Hydrochloride

Other Names

  • Naftifine HCl

Drug Class

  • Antifungal medication

Chemical Formula

C21H21ClN2

Molecular Weight

344.855 g/mol

Mechanism of Action

  • Naftifine hydrochloride exerts its antifungal activity by inhibiting the enzyme squalene epoxidase, leading to ergosterol deficiency and accumulation of toxic squalene in fungal cells.

Indications

  • Treatment of tinea corporis (ringworm)
  • tinea cruris (jock itch)
  • and tinea pedis (athlete's foot) caused by certain types of fungi

Common Dosage Forms

  • Topical cream
  • gel
  • solution

Typical Dosage

  • Apply a thin layer of cream or gel on the affected area once daily for 2-4 weeks

Pediatric Dosage

  • Dosage for pediatric patients should be determined by a healthcare provider

Geriatric Dosage

  • Dosage adjustments may be required for elderly patients with impaired liver or kidney function

Side Effects

  • Common side effects may include mild itching, burning, or stinging at the application site
  • Rare side effects may include blistering, peeling, or severe irritation

Contraindications

  • Hypersensitivity to naftifine hydrochloride or any component of the formulation

Pregnancy Category

  • Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women

Lactation Safety

  • Caution advised while using naftifine hydrochloride during lactation, consult a healthcare provider for guidance

Drug Interactions

  • No significant drug interactions reported with topical naftifine hydrochloride

Overdose Symptoms

  • An overdose of naftifine hydrochloride is unlikely with topical use, seek medical attention if accidentally ingested

Antidote for Overdose

  • No specific antidote, treatment is symptomatic and supportive

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Minimal systemic absorption after topical administration
  • Distribution: Not well described
  • Metabolism: Metabolized in the liver
  • Excretion: Primarily eliminated in the feces

Precautions

  • Avoid contact with eyes, nose, mouth, or mucous membranes
  • Discontinue use if irritation or allergic reaction occurs

Warnings

  • For external use only
  • Not for ophthalmic, oral, or intravaginal use

Others

  • It is important to complete the full course of treatment as prescribed by a healthcare provider for effective eradication of fungal infections