Bromazepam

Generic Details

Generic Name

Bromazepam

Other Names

  • Lexotan
  • Lexotanil

Drug Class

  • Benzodiazepine

Chemical Formula

C14H10BrN3O

Molecular Weight

316.15 g/mol

Mechanism of Action

  • Enhances the effect of gamma-aminobutyric acid (GABA) by binding to the benzodiazepine site on GABA-A receptors

Indications

  • Anxiety disorders
  • Panic attacks
  • Insomnia
  • Alcohol withdrawal symptoms

Common Dosage Forms

  • Tablets

Typical Dosage

  • 3-18 mg per day in divided doses

Pediatric Dosage

  • Safety and efficacy not established for children

Geriatric Dosage

  • Lower doses may be required due to reduced metabolism and clearance

Side Effects

  • Drowsiness
  • Dizziness
  • Confusion
  • Headache
  • Nausea
  • Dry mouth

Contraindications

  • Hypersensitivity to bromazepam or other benzodiazepines
  • Severe respiratory insufficiency
  • Severe hepatic impairment

Pregnancy Category

  • Category D - Potential risk to the fetus

Lactation Safety

  • Bromazepam is excreted in breast milk, caution advised

Drug Interactions

  • Alcohol
  • Central nervous system depressants
  • Antidepressants
  • Antipsychotics

Overdose Symptoms

  • Drowsiness
  • Confusion
  • Hypotonia
  • Coma
  • Respiratory depression

Antidote for Overdose

  • Flumazenil (Benzodiazepine receptor antagonist)

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed after oral administration
  • Distribution: Crosses the blood-brain barrier and placenta, found in breast milk
  • Metabolism: Metabolized in the liver to inactive metabolites
  • Excretion: Primarily excreted in the urine

Precautions

  • Use with caution in patients with a history of substance abuse or addiction

Warnings

  • Potential for abuse and dependence
  • Avoid abrupt discontinuation to prevent withdrawal symptoms

Others

  • Avoid driving or operating machinery until the individual response to the medication is known