Bisoprolol Fumarate + Amlodipine Besilate

Generic Details

Generic Name

Bisoprolol-Fumarate-Amlodipine-Besilate

Other Names

    Drug Class

    • Antihypertensive combination

    Chemical Formula

    Molecular Weight

    Mechanism of Action

    • Bisoprolol (beta-blocker) reduces the heart rate and workload on the heart. Amlodipine (calcium channel blocker) relaxes blood vessels, allowing for easier blood flow.

    Indications

    • Hypertension (high blood pressure)

    Common Dosage Forms

    • Tablet

    Typical Dosage

    • One tablet per day, dosage may vary based on individual response

    Pediatric Dosage

    • Not recommended for pediatric use

    Geriatric Dosage

    • Dose adjustment may be necessary for elderly patients

    Side Effects

    • Dizziness
    • Fatigue
    • Fluid retention
    • Headache
    • Edema
    • Bradycardia
    • Nausea

    Contraindications

    • Severe bradycardia
    • Cardiogenic shock
    • Heart block greater than first degree
    • Severe hepatic impairment

    Pregnancy Category

    • Category C: Risk cannot be ruled out

    Lactation Safety

    • Caution advised, excretion in breast milk is unknown

    Drug Interactions

    • Avoid concomitant use with other beta-blockers or calcium channel blockers

    Overdose Symptoms

    • Hypotension
    • Bradycardia
    • Heart failure

    Antidote for Overdose

    • Intravenous fluids, atropine, glucagon

    Storage Conditions

    • Store at room temperature away from moisture and heat

    Pharmacokinetics

    • Absorption: Rapidly absorbed
    • Distribution: Widely distributed
    • Metabolism: Metabolized in the liver
    • Excretion: Excreted in urine and feces

    Precautions

    • Monitor heart rate and blood pressure regularly

    Warnings

    • Abrupt discontinuation may lead to rebound hypertension

    Others

    • This combination medication is used when blood pressure is not adequately controlled by a single antihypertensive agent.