Cabergoline
Generic Details
Generic Name
Cabergoline
Other Names
- Dostinex
- Cabaser
Drug Class
- Dopamine agonist
Chemical Formula
C26H37N5O2
Molecular Weight
451.60 g/mol
Mechanism of Action
- Cabergoline works by stimulating dopamine receptors in the brain. It is a long-acting dopamine receptor agonist with a high affinity for D2 receptors.
Indications
- Hyperprolactinemia
- Parkinson's disease
- Restless legs syndrome
Common Dosage Forms
- Tablet
Typical Dosage
- 0.25 mg twice weekly
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Adjust dosage cautiously in elderly patients
Side Effects
- Nausea
- Headache
- Dizziness
- Fatigue
- Constipation
- Orthostatic hypotension
Contraindications
- Hypersensitivity to cabergoline
- Uncontrolled hypertension
- History of fibrotic disorders
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Limited data, caution advised
Drug Interactions
- Cabergoline may interact with other dopamine agonists, antipsychotics, and medications metabolized by CYP3A4.
Overdose Symptoms
- Symptoms may include nausea, vomiting, hallucinations, and hypotension.
Antidote for Overdose
- There is no specific antidote, treatment is supportive.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the feces
Precautions
- Caution in patients with hepatic impairment
- Regular monitoring of liver enzymes recommended
Warnings
- May cause orthostatic hypotension, caution while driving or operating machinery
Others
- Cabergoline may be used off-label for the treatment of acromegaly and prolactinomas.