Bromfenac Sodium
Generic Details
Generic Name
Bromfenac Sodium
Other Names
- Bromfenac
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C15H10BrNaO3
Molecular Weight
339.09 g/mol
Mechanism of Action
- Inhibits cyclooxygenase enzymes, thereby reducing prostaglandin synthesis and inflammation
Indications
- Ophthalmic: for the treatment of postoperative inflammation and reduction of ocular pain following cataract surgery
Common Dosage Forms
- Ophthalmic solution
Typical Dosage
- 1 drop instilled into the affected eye(s) once daily
Pediatric Dosage
- Safety and effectiveness not established in pediatric patients
Geriatric Dosage
- Dosage adjustment may be needed in elderly patients
Side Effects
- Eye irritation, increased tearing, blurred vision, headache, eye pain, etc.
Contraindications
- Hypersensitivity to bromfenac or other NSAIDs
Pregnancy Category
- Category C: Risk cannot be ruled out
Lactation Safety
- Safety not established; use with caution
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Symptoms may include drowsiness, headache, nausea, and vomiting
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at controlled room temperature 15°C to 25°C (59°F to 77°F)
Pharmacokinetics
- Absorption: Well absorbed after ophthalmic administration
- Distribution: Not well defined
- Metabolism: Hepatic metabolism
- Excretion: Primarily renal excretion
Precautions
- Use with caution in patients with a history of asthma or aspirin sensitivity
Warnings
- Potential for cross-sensitivity with other NSAIDs, may delay healing