L-Ornithine L-Aspartate

Generic Name

L-ornithine-L-aspartate

Other Names

• LOLA

Drug Class

• Amino acid supplement

Chemical Formula

C9H19N3O6

Molecular Weight

277.27 g/mol

Mechanism of Action

• L-ornithine and L-aspartate are amino acids that help in the detoxification process by improving ammonia clearance in the liver.

Indications

• Hepatic encephalopathy
• Liver cirrhosis
• Ammonia detoxification

Common Dosage Forms

• Oral solution
• Tablets

Typical Dosage

• 5-10 grams three times a day

Pediatric Dosage

• Dosage based on weight and severity of condition

Geriatric Dosage

• May require dosage adjustment based on renal function

Side Effects

• Nausea
• Diarrhea
• Abdominal pain

Contraindications

• Hypersensitivity to any component of the formulation

Pregnancy Category

• Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus but there are no adequate and well-controlled studies in pregnant women.

Lactation Safety

• Use with caution, not much data available

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Severe gastrointestinal symptoms
• Neurological abnormalities

Antidote for Overdose

• Supportive care and symptom management

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Rapidly absorbed from the gastrointestinal tract
• Distribution: Distributed mainly in the liver
• Metabolism: Metabolized in the liver
• Excretion: Excreted in urine

Precautions

• Monitor renal function during prolonged use

Warnings

• Not a substitute for medical treatment of liver disease

Others

• Consult healthcare provider before use in special populations.