Mycophenolic acid
Generic Details
Generic Name
Mycophenolic Acid
Other Names
- MPA
Drug Class
- Immunosuppressant
Chemical Formula
C17H20O6
Molecular Weight
320.34 g/mol
Mechanism of Action
- Inhibits inosine monophosphate dehydrogenase, leading to decreased de novo purine synthesis in lymphocytes
Indications
- Prevention of organ rejection in patients receiving allogeneic kidney, heart, or liver transplants
Common Dosage Forms
- Tablet
- Capsule
- Oral Suspension
Typical Dosage
- 500-1500 mg twice daily
Pediatric Dosage
- Dosing based on body surface area, to be determined by healthcare provider
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Infections
- Bone marrow suppression
Contraindications
- Hypersensitivity to mycophenolic acid or its derivatives
- Pregnancy
Pregnancy Category
- Category D
Lactation Safety
- Use with caution, benefits should outweigh risks
Drug Interactions
- Proton pump inhibitors may decrease mycophenolic acid levels
Overdose Symptoms
- Increased risk of infection
- Severe neutropenia
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature
Pharmacokinetics
- Absorption: Well absorbed, with delayed absorption when taken with food
- Distribution: Distributed widely in the body, including into breast milk
- Metabolism: Metabolized in the liver to an inactive glucuronide
- Excretion: Mainly excreted in urine
Precautions
- Monitor for signs of infection
- Regular monitoring of blood cell counts and renal function
Warnings
- Increased risk of lymphoma and other malignancies
- Increased risk of opportunistic infections