Pyridoxine Hydrochloride + Doxylamine Succinate

Generic Name

Pyridoxine Hydrochloride Doxylamine Succinate

Other Names

• Pyridoxine-Doxylamine

Drug Class

• Antiemetic
• Antihistamine
• Vitamin

Chemical Formula

C17H22ClNO3 (Pyridoxine) C21H27ClN2O5 (Doxylamine) C18H22N4O6 (Succinate)

Molecular Weight

337.82 g/mol (Pyridoxine) 388.91 g/mol (Doxylamine) 386.39 g/mol (Succinate)

Mechanism of Action

• Pyridoxine (Vitamin B6) plays a role in neurotransmitter synthesis.
• Doxylamine is an H1 receptor antagonist with antihistaminic properties.

Indications

• Nausea and vomiting of pregnancy (morning sickness)

Common Dosage Forms

• Tablets
• Capsules
• Oral Solutions

Typical Dosage

• 10-25 mg pyridoxine, 10-10 mg doxylamine once daily at bedtime

Pediatric Dosage

• Not recommended for children under 18 years old

Geriatric Dosage

• Use with caution due to increased risk of side effects

Side Effects

• Drowsiness
• Dry mouth
• Constipation
• Urinary retention

Contraindications

• Hypersensitivity to any component
• Asthma
• Glaucoma
• Severe liver disease

Pregnancy Category

• Category A - Controlled studies have shown no risk

Lactation Safety

• Compatible with breastfeeding under medical supervision

Drug Interactions

• Sedatives
• Alcohol
• MAO inhibitors

Overdose Symptoms

• Seizures
• Coma
• Respiratory depression

Antidote for Overdose

• Supportive care and symptomatic treatment

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well absorbed from the gastrointestinal tract
• Distribution: Crosses the placenta; excreted in breast milk
• Metabolism: Hepatic metabolism
• Excretion: Primarily renal excretion

Precautions

• Avoid driving or operating heavy machinery due to potential drowsiness

Warnings

• May cause dizziness, avoid alcohol
• Use with caution in elderly patients