Moxifloxacin Hydrochloride + Dexamethasone

Generic Details

Generic Name

Moxifloxacin Hydrochloride Dexamethasone

Other Names

  • Moxifloxacin-Dexamethasone

Drug Class

  • Antibiotic-Corticosteroid Combination

Chemical Formula

C21H24FN3O4 (moxifloxacin) - C22H29FO5 (dexamethasone)

Molecular Weight

401.43 g/mol (moxifloxacin) - 392.47 g/mol (dexamethasone)

Mechanism of Action

  • Moxifloxacin: inhibits bacterial DNA gyrase and topoisomerase IV
  • Dexamethasone: anti-inflammatory and immunosuppressive effects

Indications

  • Otitis externa
  • Acute otitis media with tympanostomy tubes
  • Blepharitis
  • Conjunctivitis

Common Dosage Forms

  • Otic solution
  • Ophthalmic solution

Typical Dosage

  • Otic solution: 4 drops in the affected ear(s) once daily for 7 days
  • Ophthalmic solution: 1 to 2 drops in the affected eye(s) every 4 to 6 hours

Pediatric Dosage

  • Dosage adjustments may be required based on weight and age

Geriatric Dosage

  • No specific dosage adjustments needed

Side Effects

  • Hypersensitivity reactions
  • Burning or stinging sensation in the ear or eye
  • Headache
  • Taste perversion

Contraindications

  • Hypersensitivity to quinolone antibiotics or corticosteroids
  • Fungal or viral infections of the eye or ear

Pregnancy Category

  • C (moxifloxacin) - C (dexamethasone)

Lactation Safety

  • Use with caution; limited data available

Drug Interactions

  • Corticosteroids may potentiate the toxicities of some medications

Overdose Symptoms

  • Symptomatic dizziness, nausea, and gastrointestinal disturbances

Antidote for Overdose

  • No specific antidote; symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well-absorbed after topical administration
  • Distribution: Distributed widely in body tissues
  • Metabolism: Moxifloxacin undergoes hepatic metabolism
  • Excretion: Mainly excreted in urine and feces

Precautions

  • Avoid contact with eyes when using otic solution
  • Do not use for longer than prescribed duration

Warnings

  • Potential for tendon rupture with fluoroquinolones
  • May mask or exacerbate infections

Others

  • Dosage and duration of treatment should be strictly followed to prevent antimicrobial resistance