Bromhexine Hydrochloride
Generic Details
Generic Name
Bromhexine Hydrochloride
Other Names
- Bisolvon
- Bisoline
- Bisolvon Dry
- Bisolvan
Drug Class
- Mucolytic
Chemical Formula
C14H20Br2N2.HCl
Molecular Weight
412.59 g/mol
Mechanism of Action
- Bromhexine Hydrochloride works by reducing the viscosity of sputum and enhancing mucus clearance. It stimulates the production of enzymes that aid in breaking down thick, sticky mucus in the respiratory tract.
Indications
- Acute and chronic respiratory disorders associated with abnormal mucus secretion and impaired mucus transport.
Common Dosage Forms
- Tablet
- Syrup
Typical Dosage
- 8-16 mg three times a day for adults
Pediatric Dosage
- Children (6-12 years): 4-8 mg three times a day
- Children (2-6 years): 2-4 mg three times a day
Geriatric Dosage
- Dose adjustment may be needed based on renal function
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Skin rash
Contraindications
- Hypersensitivity to Bromhexine Hydrochloride
Pregnancy Category
- Use with caution in pregnancy, consult healthcare provider
Lactation Safety
- Data not available, consult healthcare provider
Drug Interactions
- May enhance the effect of antibiotics like amoxicillin and erythromycin
Overdose Symptoms
- Excessive salivation
- Nausea
- Vomiting
- Central and autonomic nervous system depression
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Caution in patients with peptic ulcer, severe liver or renal impairment
- Stay hydrated while using Bromhexine Hydrochloride
Warnings
- Discontinue use if skin rash or other allergic reactions occur
Others
- Bromhexine Hydrochloride is also available in combination with other medications for treating respiratory conditions.