Fluticasone Propionate + Formoterol Fumarate
Generic Details
Generic Name
Fluticasone Propionate Formoterol Fumarate
Other Names
- Flutiform
Drug Class
- Combination of corticosteroid and long-acting beta agonist
Chemical Formula
Molecular Weight
Mechanism of Action
- Fluticasone propionate exerts anti-inflammatory effects by inhibiting the release of inflammatory mediators. Formoterol fumarate acts as a long-acting beta agonist stimulating beta-adrenergic receptors in the lungs, leading to bronchodilation.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Common Dosage Forms
- Inhaler
Typical Dosage
- Fluticasone Propionate 113-113 mcg, Formoterol Fumarate 5-10 mcg per inhalation, twice daily
Pediatric Dosage
- Dosage should be adjusted based on weight and medical condition
Geriatric Dosage
- Dosage adjustments may be necessary based on age and health status
Side Effects
- Headache
- Throat irritation
- Cough
- Nausea
- Muscle cramps
Contraindications
- Hypersensitivity to any component of the product
- Status asthmaticus
- Acute episodes of asthma or COPD requiring intensive measures
Pregnancy Category
- Category C - Consult healthcare provider before use
Lactation Safety
- Use with caution; monitor infant for potential adverse effects
Drug Interactions
- Beta-blockers
- Monoamine oxidase inhibitors
- Tricyclic antidepressants
Overdose Symptoms
- Tremors
- Palpitations
- Hypokalemia
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after inhalation
- Distribution: Metabolized in the liver
- Metabolism: Excreted primarily in the feces and urine
- Excretion:
Precautions
- Monitor for signs of systemic corticosteroid effects
- Regularly assess lung function
Warnings
- Not intended for acute asthma or COPD exacerbations
- Do not exceed prescribed dosage
Others
- Avoid using other long-acting beta agonists concurrently