Perindopril Arginine + Amlodipine
Generic Details
Generic Name
Perindopril-arginine-amlodipine
Other Names
- Prestalia
Drug Class
- Antihypertensive Combination
Chemical Formula
C33H54N10O11
Molecular Weight
758.84 g/mol
Mechanism of Action
- Perindopril: ACE inhibitor
- Amlodipine: Calcium channel blocker
Indications
- Hypertension
Common Dosage Forms
- Tablet
Typical Dosage
- 2.5/3.5/5 mg/5 mg/10 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be needed
Side Effects
- Dizziness
- Peripheral edema
- Cough
- Headache
Contraindications
- History of angioedema related to previous ACE inhibitor therapy
Pregnancy Category
- Category D (2nd and 3rd trimesters)
Lactation Safety
- Unknown if excreted in breast milk
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
Overdose Symptoms
- Hypotension
- Bradycardia
Antidote for Overdose
- Supportive measures
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed
- Distribution: Extensively distributed
- Metabolism: Perindopril: Hepatic; Amlodipine: Hepatic
- Excretion: Perindopril: Renal; Amlodipine: Renal
Precautions
- Renal impairment
- Hepatic impairment
- Hypotension
Warnings
- Angioedema
- Hypotension
- Hyperkalemia
Others
- May cause fetal harm when administered to a pregnant woman