Dithranol + Boric Acid + Salicylic Acid

Generic Name

Dithranol-Boric Acid-Salicylic Acid

Other Names

• Coal tar paste
• Anthralin-Boric Acid-Topical-Salicylic Acid

Drug Class

• Topical antipsoriatics
• Keratolytics

Chemical Formula

Molecular Weight

Mechanism of Action

• Dithranol: Inhibits DNA synthesis in keratinocytes
• Boric Acid: Antiseptic and astringent properties
• Salicylic Acid: Keratolytic action by breaking down keratin protein

Indications

• Psoriasis
• Eczema
• Dermatitis

Common Dosage Forms

• Topical cream
• Ointment

Typical Dosage

• Apply a thin layer to affected area once daily

Pediatric Dosage

• Consult healthcare provider for appropriate dosage

Geriatric Dosage

• Adjust dosage as needed based on individual patient assessment

Side Effects

• Skin irritation
• Burning sensation
• Redness
• Dryness

Contraindications

• Hypersensitivity to any components
• Open wounds
• Severe renal impairment

Pregnancy Category

• Consult healthcare provider before use in pregnancy

Lactation Safety

• Limited data, consult healthcare provider

Drug Interactions

• No known significant drug interactions

Overdose Symptoms

• Severe skin irritation
• Increased side effects

Antidote for Overdose

• Discontinue use and seek medical attention

Storage Conditions

• Store in a cool, dry place away from direct sunlight

Pharmacokinetics

• Absorption: Limited systemic absorption due to topical application
• Distribution: Not applicable
• Metabolism: Metabolized locally in the skin
• Excretion: Not applicable

Precautions

• Avoid contact with eyes and mucous membranes
• Use sunscreen as dithranol may increase photosensitivity

Warnings

• For external use only
• Do not use on broken or infected skin

Others

• It is important to perform a patch test before widespread application to check for sensitivity.