Sodium Picosulfate
Generic Details
Generic Name
Sodium Picosulfate
Other Names
- Picosulfate sodium
- Pico-Salax
Drug Class
- Laxative
Chemical Formula
C18H13NNa2O8S3
Molecular Weight
481.43 g/mol
Mechanism of Action
- Stimulates bowel movements by increasing intestinal motility and fluid secretion
Indications
- Constipation
- Pre-operative bowel preparation
Common Dosage Forms
- Oral solution
- Tablet
Typical Dosage
- 5-10 mg once daily in the evening
Pediatric Dosage
- Consult pediatrician for appropriate dosage
Geriatric Dosage
- May require lower doses due to decreased renal function
Side Effects
- Abdominal cramps
- Diarrhea
- Electrolyte imbalance
Contraindications
- Intestinal obstruction
- Severe inflammatory conditions of the intestines
Pregnancy Category
- Category C - Safety in pregnancy not established, use with caution
Lactation Safety
- Use with caution, excreted in breast milk
Drug Interactions
- May interact with diuretics and medications that affect electrolyte balance
Overdose Symptoms
- Severe diarrhea
- Dehydration
Antidote for Overdose
- Treatment is supportive and symptomatic
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted in the urine
Precautions
- Avoid prolonged use
- Stay hydrated while taking the medication
Warnings
- Do not use for more than 7 days without medical advice