Bromocriptine Mesylate

Generic Details

Generic Name

Bromocriptine-Mesylate

Other Names

  • Parlodel
  • Cycloset
  • Chebrachon

Drug Class

  • Dopamine agonist

Chemical Formula

C32H40BrN5O5.CH4O3S

Molecular Weight

750.76 g/mol

Mechanism of Action

  • Bromocriptine acts as a dopamine D2 receptor agonist, particularly in the anterior pituitary. It inhibits the release of prolactin, resulting in decreased levels of the hormone.

Indications

  • Hyperprolactinemia
  • Prolactin-secreting adenomas
  • Acromegaly
  • Parkinson's disease

Common Dosage Forms

  • Tablet
  • Capsule

Typical Dosage

  • 2.5 mg-5 mg orally once daily with food, may increase as needed

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Dose adjustments may be required based on renal function

Side Effects

  • Nausea
  • Vomiting
  • Fatigue
  • Dizziness
  • Headache
  • Orthostatic hypotension
  • Hallucinations
  • Dyskinesia

Contraindications

  • Hypersensitivity to bromocriptine
  • Uncontrolled hypertension
  • Preeclampsia
  • Eclampsia
  • Psychotic disorders

Pregnancy Category

  • Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus, but there are no adequate studies in pregnant women

Lactation Safety

  • Compatible with breastfeeding under medical supervision

Drug Interactions

  • Ergot alkaloids
  • Dopamine antagonists
  • Drugs metabolized by CYP3A4

Overdose Symptoms

  • Nausea
  • Vomiting
  • Confusion
  • Hallucinations
  • Seizures
  • Cardiac arrhythmias

Antidote for Overdose

  • Activated charcoal
  • Symptomatic treatment

Storage Conditions

  • Store at room temperature away from light and moisture

Pharmacokinetics

  • Absorption: Well absorbed orally
  • Distribution: Crosses the blood-brain barrier and placenta; found in breast milk
  • Metabolism: Hepatic metabolism via CYP3A4
  • Excretion: Primarily renal excretion

Precautions

  • Monitor blood pressure regularly
  • Caution in patients with cardiovascular disease
  • Regular monitoring of prolactin levels for appropriate dosing

Warnings

  • May cause orthostatic hypotension, hallucinations, and sudden sleep episodes; use caution when driving or operating machinery

Others

  • Bromocriptine may be used off-label for the management of Type 2 diabetes mellitus.