Rasagiline

Generic Details

Generic Name

Rasagiline

Other Names

  • Azilect

Drug Class

  • Monoamine oxidase B (MAO-B) inhibitor

Chemical Formula

C12H13N

Molecular Weight

171.24 g/mol

Mechanism of Action

  • Irreversible inhibition of MAO-B enzyme, leading to increased levels of dopamine in the brain

Indications

  • Parkinson's disease

Common Dosage Forms

  • Tablet

Typical Dosage

  • 1 mg once daily

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Consider lower starting dose in elderly patients

Side Effects

  • Nausea
  • Headache
  • Insomnia
  • Dizziness
  • Dyskinesia

Contraindications

  • Hypersensitivity to rasagiline
  • Concomitant use with other MAO inhibitors

Pregnancy Category

  • C

Lactation Safety

  • Not recommended, excreted in breast milk

Drug Interactions

  • SSRIs, tricyclic antidepressants, meperidine, dextromethorphan, sympathomimetics

Overdose Symptoms

  • Hypertension
  • Tachycardia
  • Hyperthermia
  • Agitation

Antidote for Overdose

  • There is no specific antidote, supportive care

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration
  • Distribution: Widely distributed in the body
  • Metabolism: Primarily metabolized by CYP1A2
  • Excretion: Mainly eliminated via urine

Precautions

  • Monitor for signs of serotonin syndrome
  • Caution in patients with hepatic impairment

Warnings

  • May increase the risk of hypertensive crisis when used with tyramine-rich foods or sympathomimetic agents

Others

  • Report any new or worsening symptoms to the healthcare provider