Budesonide + Formoterol Fumarate
Generic Details
Generic Name
budesonide-formoterol-fumarate
Other Names
- Budesonide and Formoterol Fumarate Dihydrate
Drug Class
- Combination of a corticosteroid and a long-acting beta agonist
Chemical Formula
C29H34NO6S2.C19H24NO4.H2O
Molecular Weight
1113.27 g/mol
Mechanism of Action
- Budesonide is a corticosteroid that reduces inflammation, while formoterol is a long-acting beta agonist that helps in bronchodilation.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Common Dosage Forms
- Inhalation aerosol
- Inhalation powder
Typical Dosage
- Budesonide-formoterol 160mcg-4.5mcg inhalation twice a day
Pediatric Dosage
- Dosage adjustment based on weight and severity of condition
Geriatric Dosage
- May require lower doses due to age-related changes in metabolism
Side Effects
- Headache
- Throat irritation
- Tremors
- Increased heart rate
Contraindications
- Hypersensitivity to budesonide, formoterol, or related components
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Limited data available; use with caution
Drug Interactions
- Beta blockers
- Diuretics
- Monoamine oxidase inhibitors
Overdose Symptoms
- Tremors
- Headache
- Palpitations
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapid and extensive after inhalation
- Distribution: Budesonide extensively bound to plasma proteins
- Metabolism: Primarily hepatic via CYP3A4 enzyme
- Excretion: Mainly in feces
Precautions
- Monitor for signs of adrenal insufficiency
- Regularly assess lung function
Warnings
- Not for acute asthma attacks
- Do not use as monotherapy for COPD
Others
- May increase the risk of asthma-related death; use with caution in patients with asthma