Ispaghula Husk [Psyllium]
Generic Details
Generic Name
Ispaghula Husk Psyllium
Other Names
- Psyllium Husk
- Isabgol
Drug Class
- Bulk-Forming Laxative
Chemical Formula
C42H82O41
Molecular Weight
1624.2 g/mol
Mechanism of Action
- Absorbs water in the gut, forming a bulky stool that is easy to pass.
Indications
- Constipation
- Irritable bowel syndrome
- Diarrhea
- High cholesterol
Common Dosage Forms
- Powder
- Granules
- Capsules
Typical Dosage
- 2.5 to 30 grams daily, taken with at least 8 ounces of water
Pediatric Dosage
- Consult healthcare provider for appropriate dosage in children
Geriatric Dosage
- Lower doses may be needed in the elderly
Side Effects
- Bloating
- Gas
- Abdominal cramps
- Allergic reactions (rare)
Contraindications
- Esophageal stricture
- Gastrointestinal obstruction
- Difficulty swallowing
Pregnancy Category
- B
Lactation Safety
- Generally considered safe during breastfeeding
Drug Interactions
- May affect absorption of certain medications, take other drugs 1 hour before or 2-4 hours after psyllium.
Overdose Symptoms
- Severe abdominal pain
- Vomiting
- Difficulty breathing
Antidote for Overdose
- Treatment is supportive and symptomatic
Storage Conditions
- Store in a cool, dry place away from moisture and heat
Pharmacokinetics
- Absorption: Not absorbed systemically
- Distribution: N/A
- Metabolism: Not metabolized
- Excretion: Primarily through feces
Precautions
- Ensure an adequate intake of water when taking psyllium to prevent intestinal blockage
Warnings
- If sudden change in bowel habits lasts more than 2 weeks, discontinue use and consult a healthcare provider
Others
- May help with weight management by promoting a feeling of fullness