Gentamicin Sulfate (Injection)
Generic Details
Generic Name
Gentamicin Sulfate Injection
Other Names
- Gentamicin Injection
- Garamycin Injection
Drug Class
- Aminoglycoside Antibiotic
Chemical Formula
C21H43N5O7
Molecular Weight
477.60 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
Indications
- Treatment of serious infections caused by susceptible bacteria
Common Dosage Forms
- Injectable solution
Typical Dosage
- 1-3 mg/kg every 8 hours
Pediatric Dosage
- Dosing based on weight and age, consult pediatrician
Geriatric Dosage
- Dosing adjustment may be necessary based on renal function
Side Effects
- Nephrotoxicity
- Ototoxicity
- Neurotoxicity
- Allergic reactions
Contraindications
- Hypersensitivity to gentamicin
- Renal impairment
- Myasthenia Gravis
Pregnancy Category
- Category D - Positive evidence of risk
Lactation Safety
- Caution advised, excreted in breast milk
Drug Interactions
- Loop diuretics enhance ototoxicity
- Neuromuscular blockers can potentiate neuromuscular blockade
Overdose Symptoms
- Renal failure
- Hearing loss
- Muscle weakness
Antidote for Overdose
- No specific antidote, symptomatic and supportive treatment
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Poor oral absorption, well-absorbed via intramuscular or intravenous administration
- Distribution: Widely distributed in tissues and body fluids
- Metabolism: Minimally metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Monitor renal function regularly
- Adjust dosage in renal impairment
- Monitor for signs of neurotoxicity
Warnings
- Avoid concomitant use with other nephrotoxic or ototoxic drugs
Others
- Dosage adjustment is necessary in patients with renal impairment