Bumetanide

Generic Details

Generic Name

bumetanide

Other Names

  • Bumex

Drug Class

  • loop diuretic

Chemical Formula

C17H20N2O5S

Molecular Weight

364.42 g/mol

Mechanism of Action

  • Inhibits the Na-K-2Cl symporter in the thick ascending loop of Henle, leading to diuresis

Indications

  • Edema associated with congestive heart failure, hepatic and renal disease
  • Hypertension

Common Dosage Forms

  • Oral tablets
  • Injection

Typical Dosage

  • 0.5-2 mg once daily

Pediatric Dosage

  • 0.025-0.02 mg/kg/day

Geriatric Dosage

  • Lower initial doses may be required due to decreased renal function

Side Effects

  • Electrolyte imbalances (e.g., hypokalemia, hyponatremia)
  • Dehydration
  • Hypotension
  • Hypovolemia
  • Ototoxicity

Contraindications

  • Anuria
  • Hypersensitivity to sulfonamides

Pregnancy Category

  • C - Risk cannot be ruled out

Lactation Safety

  • Probably safe to use

Drug Interactions

  • Digoxin
  • Lithium
  • NSAIDs
  • Aminoglycosides

Overdose Symptoms

  • Severe electrolyte depletion
  • Hypovolemia
  • Hypotension

Antidote for Overdose

  • Supportive care and electrolyte repletion

Storage Conditions

  • Store at room temperature away from light and moisture

Pharmacokinetics

  • Absorption: Rapidly and completely absorbed from the gastrointestinal tract
  • Distribution: Highly protein-bound, distributes into the renal tubules
  • Metabolism: Primarily hepatic
  • Excretion: Mainly via the urine

Precautions

  • Monitor electrolytes regularly
  • Avoid rapid IV administration to prevent ototoxicity

Warnings

  • Avoid use in patients with sulfa allergies

Others

  • May be used to treat fluid retention in conditions such as heart failure and kidney disease